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Cayman PDD00017273
List Price $49.00 Your Price $49.00
Cayman PDD00017273 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19511-1
MFG.PART: 19511-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PDD00017273 is a poly(ADP-ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM in an enzyme assay). It maintains persistence of nuclear PAR chains in HeLa cells induced by the DNA damaging agent methylmethanesulfonate (MMS; IC50 = 37 nM). PDD00017273, in combination with MMS, increases nuclear phosphorylated H2AX (γH2AX) intensity, a marker of DNA double strand breaks, in MCF-7 cells in a concentration-dependent manner. It reduces clonogenic growth of ZR-75-1 and MDA-MB-436 cells but not HCC1937 cells (IC50s = 0.2, 0.8, and >10 μM, respectively).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[(1,3-di
CAS Number
1945950-21-9
Molecular Formula
C23H26N6O4S2
Formula Weight
514.6
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 10 mg/mL
λmax
227 nm
SMILES
O=S(C1=CC=C(N(CC2=CC(C)=NN2C)C(N3CC4=CN=C(C)S4)=O)C(C3=O)=C1)(NC5(CC5)C)=O
InChi Code
InChI=1S/C23H26N6O4S2/c1-14-9-16(27(4)25-14)12-28-20-6-5-18(35(32,33)26-23(3)7-8-23)10-19(20)21(30)29(22(28)31)13-17-11-24-15(2)34-17/h5-6,9-11,26H,7-8,12-13H2,1-4H3
InChi Key
IFWUBRBMMNTBRZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19511-1 |
|---|---|
| Supplier Part Number | 19511-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United Kingdom |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1945950-21-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |