Cayman Pertussis Toxin (islet-activating protein)

Pertussis toxin (islet-activating protein) is a toxin, first isolated from B. pertussis, that is used to study g protein-coupled receptor signaling in cells and experimental autoimmune encephalomyelitis (EAE) in animals. Pertussis toxin catalyzes the transfer of the ADP-ribose moiety of NAD to the α subunits of heterotrimeric g_i/o proteins, resulting in the receptors being uncoupled from g_i/o proteins.^, Pertussis toxin is also used as an adjuvant, given with specific antigens, to immunize animals and induce EAE, an animal model of multiple sclerosis.^, Pertussis toxin was first described as an islet-activating protein because it caused a sustained potentiation of the secretory response of pancreatic islet cells to various stimuli that stimulate g_i-linked α-adrenergic receptors.^,

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