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Cayman Podophyllotoxin
List Price $153.00 Your Price $153.00
Cayman Podophyllotoxin - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19575-500
MFG.PART: 19575-500
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Podophyllotoxin is a lignan that has been found in Podophyllum and has diverse biological activities.1,2,3,4,5 It inhibits polymerization of isolated chicken brain tubulin (IC50 = 0.6 µM) and induces mitotic arrest at the g2/M phase in CCRF CEM lymphoblastic leukemia cells when used at concentrations ranging from 0.01 to 5 µg/mL.2,3 Podophyllotoxin (5 µM) is protective against herpes simplex virus 1 (HSV-1) infection in Vero cells.4 It inhibits the proliferation of several diffuse large B cell lymphoma (DLBCL) cell lines (IC50s = 0.0098-0.017 µM).5 Podophyllotoxin is a starting material in the semisynthesis of the anticancer compounds etoposide (Item No. 12092) and teniposide (Item No. 14425).6 Formulations containing podophyllotoxin have been used in the treatment of external genital warts.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(5R,5aR,8aR,9R)-
CAS Number
518-28-5
Synonyms
- NSC 24818
- (–)-Podophyllotoxin
- PPT
Molecular Formula
C22H22O8
Formula Weight
414.4
Purity
≥98%
Formulation(Request formulation change)
A powder
Solubility(Learn about Variance in Solubility)
- DMF: 15 mg/mL
- DMSO: 15 mg/mL
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
- Ethanol: 0.14 mg/mL
- PBS (pH 7.2): slightly soluble
λmax
294 nm
SMILES
O=C(OC1)[C@]([C@@]1([H])[C@H]2O)([H])C(C3=CC(OC)=C(OC)C(OC)=C3)C4=C2C=C(OCO5)C5=C4
InChi Code
InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18?,19-,20-/m0/s1
InChi Key
YJGVMLPVUAXIQN-LBXUKJEYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19575-500 |
|---|---|
| Supplier Part Number | 19575-500 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 518-28-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |