Cayman 6-Methylsulfinylhexyl isothiocyanate

6-Methylsulfinylhexyl isothiocyanate (6-MSITC) is an isothiocyanate that has been found in wasabi (W. japonica) and has diverse biological activities.^,,,, It inhibits nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at a concentration of 5 µM. It inhibits aggregation of isolated human platelets induced by arachidonic acid (Item Nos. | | ; IC₅₀ = 21.9 µM). 6-MSITC reduces cell survival in a panel of breast, brain, colon, lung, ovarian, renal, and prostate cancer cell lines (mean IC₅₀ = 43.7 µM). In vivo, 6-MSITC (5 mg/kg twice weekly) reduces apoptosis of substantia nigral dopaminergic neurons and motor dysfunction in a mouse model of Parkinsons disease induced by 6-OHDA (Item No. ). 6-MSITC also reduces the number of lung metastases in a B16/F10 murine melanoma model.

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