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Cayman 23-cGAMP (sodium salt)
List Price
$285.00
Your Price
$285.00
Cayman 23-cGAMP (sodium salt) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-19887-1
MFG.PART:
19887-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
2’3’-cGAMP is a second messenger produced from ATP and GTP by cGMP-AMP synthase (cGAS) in the cytoplasm of mammalian cells in response to the presence of DNA.,, It contains a non-canonical 2’5’-phosphodiester bond and binds tightly to the adapter protein STING (stimulator of interferon genes) with a Kd value of 3.79 nM, which is significantly lower than that observed for 2’2’-cGAMP, 3’3’-cGAMP (Item No. ), cyclic di-GMP (Item No. ), and 3’2’-cGAMP (Kds = 0.287, 1.04, 1.21, and 1.61 µM, respectively). It is a potent inducer of IFN-β mRNA expression with an EC50 value of 19.4 nM in L929 cells.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
adenylyl-(3→
Synonyms
- 23-Cyclic GMP-AMP
- Guanosine-Adenosine 2,3-cyclic monophosphate
Molecular Formula
C20H22N10O13P2 • 2Na
Formula Weight
718.4
Purity
≥98%
Formulation
A solid
Solubility
- Water: Soluble
SMILES
O=P1([O-])O[C@]([C@@H](O)[C@H](N2C=NC3=C2N=CN=C3N)O4)([H])[C@@]4([H])COP(O[C@@]5([H])[C@H](N6C=NC7=C6NC(N)=NC7=O)O[C@]([C@H]5O)([H])CO1)([O-])=O.[Na+].[Na+]
InChi Code
InChI=1S/C20H24N10O13P2.2Na/c21-14-8-15(24-3-23-14)29(4-25-8)18-11(32)12-7(41-18)2-39-45(36,37)43-13-10(31)6(1-38-44(34,35)42-12)40-19(13)30-5-26-9-16(30)27-20(22)28-17(9)33;;/h3-7,10-13,18-19,31-32H,1-2H2,(H,34,35)(H,36,37)(H2,21,23,24)(H3,22,27,28,33);;/q;2*+1/p-2/t6-,7-,10-,11-,12-,13-,18-,19-;;/m1../s1
InChi Key
CNVCOPPPOWRJAV-DQNSRKNCSA-L
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19887-1 |
|---|---|
| Supplier Part Number | 19887-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | Germany |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2734858-36-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |