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Cayman PD-1/PD-L1 Inhibitor 1
List Price $40.00 Your Price $40.00
Cayman PD-1/PD-L1 Inhibitor 1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19914-1
MFG.PART: 19914-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PD-1/PD-L1 is an inhibitor of the protein-protein interaction between programmed cell death protein 1 (PD-1) and PD-1 ligand (PD-L1). It inhibits the PD-1/PD-L1 interaction in a time-resolved FRET (TR-FRET) assay (IC50 = 6-100 nM). PD-1/PD-L1 inhibitor 1 reduces LPS-induced increases in PD-1 levels and apoptosis in MH-S mouse alveolar macrophages when used at a concentration of 1 µM. Surgical neointimal patching with PD-1/PD-L1-coated patches decreases neointimal thickness and inflammatory cell accumulation in a rat model of patch angioplasty.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(2S)-1-[[2,6-
CAS Number
1675201-83-8
Synonyms
- BMS-1
- Programmed Cell Death 1/Programmed Cell Death-Ligand 1 Inhibitor 1
Molecular Formula
C29H33NO5
Formula Weight
475.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- :
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 20 mg/mL
- PBS (pH 7.2): 1 mg/mL
λmax
211, 236, 270 nm
SMILES
O=C(O)[C@@H]1CCCCN1CC2=C(OC)C=C(OCC3=C(C)C(C4=CC=CC=C4)=CC=C3)C=C2OC
InChi Code
InChI=1S/C29H33NO5/c1-20-22(12-9-13-24(20)21-10-5-4-6-11-21)19-35-23-16-27(33-2)25(28(17-23)34-3)18-30-15-8-7-14-26(30)29(31)32/h4-6,9-13,16-17,26H,7-8,14-15,18-19H2,1-3H3,(H,31,32)/t26-/m0/s1
InChi Key
ZBOYJODMIAUJHH-SANMLTNESA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19914-1 |
|---|---|
| Supplier Part Number | 19914-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1675201-83-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |