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Cayman NVP-TNKS656
List Price $842.00 Your Price $842.00
Cayman NVP-TNKS656 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-19930-10
MFG.PART: 19930-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
NVP-TNKS656 is an orally bioavailable inhibitor of tankyrase 2 (TNKS2; IC50 = 6 nM).1 It is selective for TNKS2 over poly(ADP-ribose) polymerase (PARP) 1 and 2 (IC50s = >19 and 32 nM, respectively). NVP-TNKS656 inhibits Wnt ligand-induced signaling with an IC50 value of 3.5 nM in an HEK293 cell reporter assay. In vivo, NVP-TNKS656 (350 mg/kg) reduces Axin 2 mRNA expression, a Wnt/β-catenin target gene, in MMTV-Wnt1 tumor bearing mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-
CAS Number
1419949-20-4
Molecular Formula
C27H34N4O5
Formula Weight
494.6
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 33 mg/mL
- DMSO: 33 mg/mL
- DMSO:PBS(pH 7.2) (1:4): 0.20 mg/mL
λmax
279 nm
SMILES
O=C(N=C(CN(CC1CC1)C(CN2CCC(C(C3=CC=C(OC)C=C3)=O)CC2)=O)N4)C5=C4CCOC5
InChi Code
InChI=1S/C27H34N4O5/c1-35-21-6-4-19(5-7-21)26(33)20-8-11-30(12-9-20)16-25(32)31(14-18-2-3-18)15-24-28-23-10-13-36-17-22(23)27(34)29-24/h4-7,18,20H,2-3,8-17H2,1H3,(H,28,29,34)
InChi Key
DYGBNAYFDZEYBA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19930-10 |
|---|---|
| Supplier Part Number | 19930-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1419949-20-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |