Cayman CAY10717

CAY10717 is a multi-targeted kinase inhibitor that exhibits greater than 40% inhibition of 34 of 104 kinases in an enzymatic assay at a concentration of 100 nM. It has activity at multiple oncogenic kinases, with IC₅₀ values less than 50 nM against wild-type EGFR and ABL and mutant ABLG^250E, ABL^Y253F, ABL^E255K, and B-Raf^V600E. CAY10717 is highly cytotoxic against a cancer cell panel that includes chemotherapy-sensitive and -resistant cell lines (EC₅₀s = 0.4-158 nM). It also inhibits the growth of human umbilical vein endothelial cells (HUVECs; EC₅₀ = 34 nM), a model for tumor angiogenesis.

WARNING This product is not for human or veterinary use.