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Cayman NVS-PAK1-1
List Price
$240.00
Your Price
$240.00
Cayman NVS-PAK1-1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-19964-10
MFG.PART:
19964-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
NVS-PAK1-1 is an allosteric inhibitor of p21-activated kinase 1 (PAK1), a non-receptor serine/threonine kinase involved in tumorigenesis (Kd = 7 nM). It has an IC50 value of 5.2 nM in a PAK1 dephosphorylation assay. NVS-PAK1-1 is selective for PAK1 over PAK2 (Kd = 400 nM) and over a panel of 442 kinases, where it did not inhibit any other kinases by greater than 80%., It inhibits phosphorylation of MEK Ser289 when used at concentrations ranging from 6 to 20 µM but does not inhibit proliferation of Su86.86 cells at concentrations lower than 2 µM. See the website for more information.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3S)-3-[[2-
CAS Number
1783816-74-9
Molecular Formula
C23H25ClF3N5O
Formula Weight
479.9
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 50 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 50 mg/mL
- Ethanol: 20 mg/mL
λmax
264 nm
SMILES
FC(F)CN1C2=C(C=C(Cl)C=C2)C(N[C@H]3CCN(C(NC(C)C)=O)C3)=NC4=C1C=CC(F)=C4
InChi Code
InChI=1S/C23H25ClF3N5O/c1-13(2)28-23(33)31-8-7-16(11-31)29-22-17-9-14(24)3-5-19(17)32(12-21(26)27)20-6-4-15(25)10-18(20)30-22/h3-6,9-10,13,16,21H,7-8,11-12H2,1-2H3,(H,28,33)(H,29,30)/t16-/m0/s1
InChi Key
OINGHOPGNMYCAB-INIZCTEOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-19964-10 |
|---|---|
| Supplier Part Number | 19964-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1783816-74-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |