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Cayman HG-10-102-01
List Price
$132.00
Your Price
$132.00
Cayman HG-10-102-01 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-20049-5
MFG.PART:
20049-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
HG-10-102-01 is an inhibitor of leucine-rich repeat kinase 2 (LRRK2; IC50 = 20.3 nM).1 It also inhibits the G2019S, A2016T, and [G2019S+A2016T] mutants of LRRK2 (IC50s = 3.2, 153, and 95.9 nM, respectively).1 HG-10-102-01 substantially inhibits Ser910 and Ser935 phosphorylation of both wild-type and G2019S mutant LRRK2 in cells. When given intraperitoneally, HG-10-102-01 penetrates the blood-brain barrier and inhibits phosphorylation of LRRK2 in the brain as well as the kidney and spleen.1
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
[4-[[5-chloro
CAS Number
1351758-81-0
Molecular Formula
C17H20ClN5O3
Formula Weight
377.8
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
- Ethanol: 0.3 mg/mL
λmax
225, 275, 309 nm
SMILES
O=C(C1=CC(OC)=C(NC2=NC=C(Cl)C(NC)=N2)C=C1)N3CCOCC3
InChi Code
InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22)
InChi Key
YEVOZZZLKJKCCD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20049-5 |
|---|---|
| Supplier Part Number | 20049-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1351758-81-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |