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Cayman Pixantrone (maleate)
List Price $186.00 Your Price $186.00
Cayman Pixantrone (maleate) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20055-10
MFG.PART: 20055-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Pixantrone is a DNA topoisomerase II inhibitor.1 It induces SV40 DNA cleavage in the presence of mouse topoisomerase II and induces DNA single-strand breaks in NCI H187 cells in a concentration-dependent manner. Pixantrone is cytotoxic to L1210 leukemia cells as well as doxorubicin-sensitive and -resistant LoVo colon adenocarcinoma cells (IC50 = 0.01, 0.24, and 7.2 µg/mL, respectively).2 It decreases disease severity in a rat model of myasthenia gravis induced by immunization with the T. californica acetylcholine receptor (AChR) when administered at a dose of 8.12 mg/kg once per week for six weeks.3 Formulations containing pixantrone have been used in the treatment of non-Hodgkin B cell lymphoma.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6,9-bis[(2-
CAS Number
144675-97-8
Synonyms
- BBR 2778
Molecular Formula
C17H19N5O2 • 2C4H4O4
Formula Weight
557.5
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMSO: 1 mg/mL
λmax
214, 324, 513 nm
SMILES
NCCNC1=C2C(C(C(C=CN=C3)=C3C2=O)=O)=C(NCCN)C=C1.OC(/C=C\C(O)=O)=O.OC(/C=C\C(O)=O)=O
InChi Code
InChI=1S/C17H19N5O2.2C4H4O4/C18-4-7-21-12-1-2-13(22-8-5-19)15-14(12)16(23)10-3-6-20-9-11(10)17(15)24;2*5-3(6)1-2-4(7)8/h1-3,6,9,21-22H,4-5,7-8,18-19H2;2*1-2H,(H,5,6)(H,7,8)/b;2*2-1-
InChi Key
SVAGFBGXEWPNJC-SPIKMXEPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20055-10 |
|---|---|
| Supplier Part Number | 20055-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 144675-97-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |