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Cayman SGI-7079
List Price $36.00 Your Price $36.00
Cayman SGI-7079 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20111-1
MFG.PART: 20111-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SGI-7079 is an inhibitor of the receptor tyrosine kinase Axl. It inhibits proliferation of inflammatory breast cancer cells (IC50s = 0.43 and 0.15 µM for SUM149 and KPL-4 cells, respectively), decreases invasion, and halts the cell cycle in the g1 phase. SGI-7079 synergistically increases the potency of erlotinib (Item No. ) on EGFR inhibition. In a mouse xenograft model of non-small cell lung cancer, SGI-7079 dose-dependently inhibits tumor growth, an effect that is greater when used in combination with erlotinib.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3-[2-[[3-fluoro-
CAS Number
1239875-86-5
Molecular Formula
C26H26FN7
Formula Weight
455.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
λmax
285 nm
SMILES
CN1CCN(C2=C(F)C=C(NC3=NC(C4=CC(CC#N)=CC=C4)=C(C(C)=CN5)C5=N3)C=C2)CC1
InChi Code
InChI=1S/C26H26FN7/c1-17-16-29-25-23(17)24(19-5-3-4-18(14-19)8-9-28)31-26(32-25)30-20-6-7-22(21(27)15-20)34-12-10-33(2)11-13-34/h3-7,14-16H,8,10-13H2,1-2H3,(H2,29,30,31,32)
InChi Key
BCFKACXAIBEPKR-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20111-1 |
|---|---|
| Supplier Part Number | 20111-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1239875-86-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |