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Cayman K-Ras(G12C) Inhibitor 12
List Price $36.00 Your Price $36.00
Cayman K-Ras(G12C) Inhibitor 12 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20118-1
MFG.PART: 20118-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
K-Ras(G12C) inhibitor 12 irreversibly binds to the oncogenic mutant K-Ras(G12C), blocking K-Ras(G12C) interactions. K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. This compound has been used to decrease viability and increase apoptosis in several lung cancer cell lines containing G12C mutations (EC50 = 0.32 µM in H1792 cells).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-[4-[2-[(4-
CAS Number
1469337-95-8
Synonyms
- K-Ras4A(G12C) Inhibitor 12
- c-K-ras(G12C) Inhibitor 12
- Ki-Ras(G12C) Inhibitor 12
- c-Ki-ras(G12C) Inhibitor 12
- KRAS(G12C) Inhibitor 12
- Kristen Rat Sarcoma Virus(G12C) Inhibitor 12
Molecular Formula
C15H17ClIN3O3
Formula Weight
449.7
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 0.33 mg/mL
λmax
220, 254, 307 nm
SMILES
IC1=C(Cl)C=C(O)C(NCC(N2CCN(C(C=C)=O)CC2)=O)=C1
InChi Code
InChI=1S/C15H17ClIN3O3/c1-2-14(22)19-3-5-20(6-4-19)15(23)9-18-12-8-11(17)10(16)7-13(12)21/h2,7-8,18,21H,1,3-6,9H2
InChi Key
JFIFBWVNHLXJFY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20118-1 |
|---|---|
| Supplier Part Number | 20118-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1469337-95-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |