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Cayman SR 48692
List Price
$36.00
Your Price
$36.00
Cayman SR 48692 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-20124-1
MFG.PART:
20124-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
SR 48692 is an orally bioavailable allosteric antagonist of the neurotensin receptor NTS1 (Kd = 3.4 nM)., SR 48692 inhibits high affinity neurotensin binding to brain tissue from guinea pig, newborn mouse, newborn human, and adult human as well as rat mesencephalic cells and HT-29 cells with IC50 values ranging from 0.99 to 30.3 nM. It blocks neurotensin-induced intracellular calcium mobilization in HT-29 cells with a Ki value of 7.4 nM. SR 48692 (10 μM) inhibits NCI-H209 and NCI-H345 cell proliferation by approximately 70 and 80%, respectively. In vivo, SR 48692 (10 μg per day) reduces tumor volume and cell proliferation in an NCI-H209 mouse xenograft model. SR 48692 (80 μg/kg, p.o.) reduces contralateral turning induced by neurotensin (Item No. ) administration in mice by 85%. Daily administration of SR 48692 for five days in rats delays sensitization to the locomotor activating effects of cocaine during three additional cocaine challenges when given seven days prior to cocaine delivery but not under a cotreatment regimen.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[[[1-(7-
CAS Number
146362-70-1
Molecular Formula
C32H31ClN4O5
Formula Weight
587.1
Purity
≥98%
Formulation
A solid
Solubility
- DMSO: 20 mm
λmax
233 nm
SMILES
COC1=CC=CC(OC)=C1C2=CC(C(N[C@@]3(C(O)=O)[C@@H](C4)C[C@@H]5C[C@H]3C[C@H]4C5)=O)=NN2C6=C(C=CC(Cl)=C7)C7=NC=C6
InChi Code
InChI=1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)/t17-,18+,19-,20+,32?
InChi Key
DYLJVOXRWLXDIG-SHXBVJGHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20124-1 |
|---|---|
| Supplier Part Number | 20124-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 146362-70-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |