Cayman 12-epi Leukotriene B4

Leukotriene B₄ (LTB₄) compounds are produced by both enzymatic and non-enzymatic processes. The products of enzymatic origin, via Leukotriene A₄ (LTA₄) hydrolase, are stereospecifically 12(R). Non-enzymatic hydrolysis products are 50:50 mixtures at C-12, but are almost exclusively trans at C-6. Thus, the non-enzymatic hydrolysis product of LTA₄ is 6-trans-12-epi LTB₄. 12-epi LTB₄ is an isomer which would not be expected to occur in either non-enzymatic hydrolysis products, or in the enzymatic products of LTA₄ hydrolase. Compared to LTB₄, 12-epi LTB₄ has significantly reduced activity for the LTB₄ receptor on human neutrophils (IC₅₀ of 7.5 mm), and on guinea pig lung membranes with a (K_i of 4.7 mm). 12-epi LTB₄ is an weak agonist at both the recombinant human BLT₁ and BLT₂ receptors, requiring approximately 10 mm for full activation of the receptor.

WARNING This product is not for human or veterinary use.