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Cayman A-395 (hydrochloride)
List Price $41.00 Your Price $41.00
Cayman A-395 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20257-1
MFG.PART: 20257-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
A-395 is an inhibitor of the interaction between embryonic ectoderm development (EED) and histone H3 lysine 27 (H3K27) that binds to the EED subunit of polycomb repressor complex 2 (PRC2) and inhibits H3K27 methylation (Ki = 0.4 nM). It inhibits H3K27 di- and trimethylation in RD rhabdoid tumor cells (IC50s = 390 and 90 nM, respectively). In vivo, A-395 (200 mg/kg) reduces tumor volume and intratumor H3K27 trimethylation in a Pfeiffer diffuse large B cell lymphoma (DLBCL) mouse xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3R,4S)-1-(7-
Molecular Formula
C26H35FN4O2S • XHCl
Formula Weight
486.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- Water: soluble
λmax
254 nm
SMILES
CS(N1CCN(C2=CC=C([C@H]3CN(C4CCC5=C4C(F)=CC=C5)C[C@@H]3N(C)C)C=C2)CC1)(=O)=O.Cl
InChi Code
InChI=1S/C26H35FN4O2S.ClH/c1-28(2)25-18-30(24-12-9-20-5-4-6-23(27)26(20)24)17-22(25)19-7-10-21(11-8-19)29-13-15-31(16-14-29)34(3,32)33;/h4-8,10-11,22,24-25H,9,12-18H2,1-3H3;1H/t22-,24?,25+;/m1./s1
InChi Key
JUZXQLNCGDDSMJ-NNEMXYTISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20257-1 |
|---|---|
| Supplier Part Number | 20257-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| Energy Star | No |
| Green | No |
| Controlled | N |