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Cayman GSK481
List Price $36.00 Your Price $36.00
Cayman GSK481 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20308-1
MFG.PART: 20308-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
GSK481 is an inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1 or RIPK1) that blocks autophosphorylation of Ser166 on wild-type human RIP1 with an IC50 value of 2.8 nM. It is selective for RIP1 over a panel of over 450 other kinases, including RIP3., GSK481 inhibits RIP1 from human and cynomolgus monkey but is at least 100-fold less potent against non-primate RIP1.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(phenyl
CAS Number
1622849-58-4
Molecular Formula
C21H19N3O4
Formula Weight
377.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 25 mg/mL
- DMSO: 30 mg/mL
- Ethanol: 30 mg/mL
- Ethanol:PBS (pH 7.2) (1:10): 0.09 mg/mL
λmax
238 nm
SMILES
O=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@@H](COC(C=CC=C3)=C3N4C)C4=OO=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@@H](COC(C=CC=C3)=C3N4C)C4=O
InChi Code
InChI=1S/C21H19N3O4/c1-24-18-9-5-6-10-19(18)27-13-17(21(24)26)22-20(25)16-12-15(28-23-16)11-14-7-3-2-4-8-14/h2-10,12,17H,11,13H2,1H3,(H,22,25)/t17-/m0/s1
InChi Key
KNOUWGGQMADIBV-KRWDZBQOSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20308-1 |
|---|---|
| Supplier Part Number | 20308-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1622849-58-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |