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Cayman Tetrabenazine
List Price $135.00 Your Price $135.00
Cayman Tetrabenazine - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20380-100
MFG.PART: 20380-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Tetrabenazine is an inhibitor of vesicular monoamine transporter 2 (VMAT2) that is selective over VMAT1 (Kis = 97 and >20,000 nM, respectively, in a serotonin uptake assay).1 It dose-dependently reduces levels of the monoamines norepinephrine (Item No. 16673), dopamine (Item No. 21992), and serotonin (5-HT; Item No. 14332) in rat brain and has been used to induce depressive-like behavior in animal models.2,3 Tetrabenazine (5 mg/kg) improves performance in balance beam and rotarod tests and prevents decreases in the number of striatal medium spiny neurons (MSNs) in a YAC128 transgenic mouse model of Huntingtons disease.4 Formulations containing tetrabenazine have been used in the treatment of chorea associated with Huntingtons disease.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
rel-1,3R,4,6,
CAS Number
58-46-8
Synonyms
- NSC 169886
- NSC 172187
- Ro 1-9569
- TBZ
Molecular Formula
C19H27NO3
Formula Weight
317.4
Purity
≥98% (mixture of enantiomers)
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF:PBS(pH7.2) (1:2): 0.33 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 10 mg/mL
λmax
285 nm
SMILES
O=C1[C@@H](CC(C)C)CN2[C@@](C(C=C(OC)C(OC)=C3)=C3CC2)([H])C1
InChi Code
InChI=1S/C19H27NO3/c1-12(2)7-14-11-20-6-5-13-8-18(22-3)19(23-4)9-15(13)16(20)10-17(14)21/h8-9,12,14,16H,5-7,10-11H2,1-4H3/t14-,16-/m0/s1
InChi Key
MKJIEFSOBYUXJB-HOCLYGCPSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20380-100 |
|---|---|
| Supplier Part Number | 20380-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 58-46-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |