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Cayman PSC 833
List Price $74.00 Your Price $74.00
Cayman PSC 833 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20391-1
MFG.PART: 20391-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PSC 833 is a non-immunosuppressant derivative of cyclosporine and potent multidrug-resistance (MDR) modulator. It restores sensitivity of MDR-P388 murine leukemia cells to cytostatic agents when used at concentrations of 70, 33, 45, 34, and 26 nM in combination with colchicine, vincristine (Item No. ), daunorubicin (Item No. ), doxorubicin (Item No. ), and etoposide (Item No. ), respectively. PSC 833 inhibits basal-to-apical transport and increases apical-to-basal transport of [14C]docetaxel in LLC-GA5-COLO150 cells that overexpress human P-glycoprotein (P-gp). In vivo, PSC 833 increases survival time in MDR-P388 tumor-bearing mice and in an MDR-L1210 leukemia mouse xenograft model when administered in combination with doxorubicin., PSC 833 also prolongs the anti-hyperalgesic effects of intraperitoneally administered pregabalin in a mouse model of cold stress-induced central pain.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[(2S,4R,6E)-
CAS Number
121584-18-7
Synonyms
- Valspodar
Molecular Formula
C63H111N11O12
Formula Weight
1214.6
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 20 mg/mL
- DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL
- DMSO: 3 mg/mL
- Ethanol: 14 mg/mL
SMILES
C[C@H](C/C=C/C)C([C@@H](C(N[C@H](C(N(CC(N(C)[C@H](C(N[C@@H](C(C)C)C(N(C)[C@H]1CC(C)C)=O)=O)CC(C)C)=O)C)=O)C(C)C)=O)N(C([C@H](C(C)C)N(C([C@@H](N(C([C@H](CC(C)C)N(C([C@H](NC([C@@H](NC1=O)C)=O)C)=O)C)=O)C)CC(C)C)=O)C)=O)C)=O
InChi Code
InChI=1S/C63H111N11O12/c1-26-27-28-41(16)53(76)52-57(80)67-49(38(10)11)61(84)68(19)33-48(75)69(20)44(29-34(2)3)56(79)66-50(39(12)13)62(85)70(21)45(30-35(4)5)55(78)64-42(17)54(77)65-43(18)58(81)71(22)46(31-36(6)7)59(82)72(23)47(32-37(8)9)60(83)73(24)5
InChi Key
YJDYDFNKCBANTM-QCWCSKBGSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20391-1 |
|---|---|
| Supplier Part Number | 20391-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 121584-18-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |