Cayman Ubiquitin (human, recombinant; His-tagged)

Ubiquitin is a regulatory protein encoded by three gene classes in humans, which code for fusion proteins between ubiquitin and zinc-finger proteins, ribosomal proteins, or ubiquitin repeats that are cleaved by esterases to release monomeric ubiquitin.^, It is ubiquitously expressed and highly conserved among eukaryotic species. Ubiquitin is conjugated to misfolded, abnormal, short-lived, or foreign proteins by ubiquitin-conjugating enzymes (E2) and substrate-specific ubiquitin ligases (E3) to target them for degradation by the 26S proteasome or lysosome.^, It is also conjugated to proteins to modify cell signaling through regulation of protein-protein interactions, activity, or subcellular localization. Dysregulation of ubiquitination has been implicated in the pathogenesis of neurodegenerative diseases, including Parkinson’s and Alzheimer’s diseases. Cayman’s Ubiquitin (human, recombinant; His-tagged) protein can be used as a substrate for enzyme activity assays, as well as for ELISA and Western blot (WB) applications.

WARNING This product is not for human or veterinary use.