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Cayman PLX7904
List Price $42.00 Your Price $42.00
Cayman PLX7904 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20710-1
MFG.PART: 20710-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PLX7904 is a RAF inhibitor (IC50s = 2.4, 140, and 91 nM for mutant B-RAFV600E, wild-type B-RAF, and C-RAF, respectively). It inhibits phosphorylation of ERK in A375 and COLO 829 cells (IC50s = 16 and 18 nM, respectively). Unlike PLX4032 (Item No. ), BAY 43-9006 (Item No. ), and dabrafenib (Item No. ), PLX7904 does not induce paradoxical pERK activation and proliferation of cancer cell lines (EC50s = >200 μM). PLX7904 (25 mg/kg twice per day) inhibits tumor growth in a mouse COLO 205 colon cancer xenograft model.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[3-[[5-(2-
CAS Number
1393465-84-3
Molecular Formula
C24H22F2N6O3S
Formula Weight
512.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: >5mg/mL
λmax
258, 305 nm
SMILES
O=C(C1=C(F)C(NS(N(CC)C)(=O)=O)=CC=C1F)C2=CNC(C2=C3)=NC=C3C4=CN=C(C5CC5)N=C4
InChi Code
InChI=1S/C24H22F2N6O3S/c1-3-32(2)36(34,35)31-19-7-6-18(25)20(21(19)26)22(33)17-12-30-24-16(17)8-14(9-29-24)15-10-27-23(28-11-15)13-4-5-13/h6-13,31H,3-5H2,1-2H3,(H,29,30)
InChi Key
DKNZQPXIIHLUHU-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20710-1 |
|---|---|
| Supplier Part Number | 20710-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1393465-84-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |