We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman FRAX1036
List Price $52.00 Your Price $52.00
Cayman FRAX1036 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20711-1
MFG.PART: 20711-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
FRAX1036 is a selective inhibitor of p21-activated kinase 1 (PAK1), a serine/threonine kinase downstream of Rac1 and Cdc42 that is involved in tumorigenesis. It can induce apoptosis in breast cancer cells and has been shown to potentiate the activity of the microtubule stabilizing agent, docetaxel (Item No. ). Disruption of PAK1 via FRAX1036 has been used to inhibit oncogenic KRAS signaling in non-small cell lung cancer cells.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[2-chloro-
CAS Number
1432908-05-8
Molecular Formula
C28H32ClN7O
Formula Weight
518.1
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 1 mg/mL
- DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL
- Ethanol: 0.33 mg/mL
λmax
211, 299, 308, 355 nm
SMILES
CN1CCC(CCNC2=NC=C(C=C(C3=C(Cl)C=C(C4=NC(C)=CN=C4)C=C3)C(N5CC)=O)C5=N2)CC1
InChi Code
InChI=1S/C28H32ClN7O/c1-4-36-26-21(16-32-28(34-26)31-10-7-19-8-11-35(3)12-9-19)13-23(27(36)37)22-6-5-20(14-24(22)29)25-17-30-15-18(2)33-25/h5-6,13-17,19H,4,7-12H2,1-3H3,(H,31,32,34)
InChi Key
RYCBSFIKWACFBY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20711-1 |
|---|---|
| Supplier Part Number | 20711-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1432908-05-8 |
| Energy Star | No |
| Green | No |
| Controlled | N |