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Cayman Dicoumarol
List Price $22.00 Your Price $22.00
Cayman Dicoumarol - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20764-1
MFG.PART: 20764-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Dicoumarol is a competitive inhibitor of NADH:quinone oxidoreductase (NQO1) with IC50 values of 2.6 and 404 nM in the absence and presence of 2 μM BSA, respectively. It has antiproliferative activity against MIA PaCa-2 pancreas and HCT116 colon carcinoma cells (IC50s = 52 and 19 μM, respectively, after a 96 hour incubation). Dicoumarol inhibits stress-activated protein kinase (SAPK) in HEK293 cells (IC50 = 19-33 μM) at a point upstream of MEKK1 and downstream of TNF receptor-associated factor 2 (TRAF2), and it inhibits TNF-α and LPS-induced NF-κB activation in HeLa cells. It also has antiproliferative activity against FL5.12 lymphocytic and MCF-7 breast carcinoma cells (100 μM) by suppressing JNK activation.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3,3-methylenebis
CAS Number
66-76-2
Synonyms
- NSC 17860
- NSC 41834
- NSC 221570
Molecular Formula
C19H12O6
Formula Weight
336.3
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 1.25 mg/mL
- DMSO: 2.5 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: slight solubility
λmax
309 nm
SMILES
O=C1C(CC2=C(O)C(C=CC=C3)=C3OC2=O)=C(O)C4=CC=CC=C4O1
InChi Code
InChI=1S/C19H12O6/c20-16-10-5-1-3-7-14(10)24-18(22)12(16)9-13-17(21)11-6-2-4-8-15(11)25-19(13)23/h1-8,20-21H,9H2
InChi Key
DOBMPNYZJYQDGZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20764-1 |
|---|---|
| Supplier Part Number | 20764-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 66-76-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |