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Cayman TX-1918
List Price $36.00 Your Price $36.00
Cayman TX-1918 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20840-1
MFG.PART: 20840-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
TX-1918 is a cell-permeable tyrphostin derivative that inhibits eukaryotic elongation factor-2 kinase (eEF-2K; IC50 = 440 nM). It inhibits Src, PKA, PKC, and EGFR kinases at much higher concentrations (IC50s = 4.4, 44, 44, and 440 µM, respectively). TX-1918 disrupts the proliferation of HepG2 and HCT116 tumor cells (EC50s = 2.07 and 230 µM, respectively) with ≥5,000-fold and ≥90-fold reduced mitochondrial- and hepato-toxicity, respectively when compared with the tyrphostin AG-17 (Item No. ).
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[(4-hydroxy
CAS Number
503473-32-3
Molecular Formula
C14H12O3
Formula Weight
228.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: slightly
- DMSO: 0.33 mg/mL
- Ethanol: slightly
λmax
220, 248, 370 nm
SMILES
CC1=C(O)C(C)=CC(/C=C2C(C=CC\2=O)=O)=C1
InChi Code
InChI=1S/C14H12O3/c1-8-5-10(6-9(2)14(8)17)7-11-12(15)3-4-13(11)16/h3-7,17H,1-2H3
InChi Key
YHWRISYBKMXSGJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20840-1 |
|---|---|
| Supplier Part Number | 20840-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 503473-32-3 |
| Energy Star | No |
| Green | No |
| Controlled | N |