Cayman Ml-356; Purity- Greater Than Or Equal To 98%; Size- 5 Mg;

4-Hydroxyphenylacetic acid is a phenolic acid with anti-inflammatory and anti-steatotic activities.^, It is formed via microbial metabolism of aromatic amino acids and polyphenolic compounds, including flavonoid glycosides, by gut microbiota.^,, 4-Hydroxyphenylacetic acid (100 mg/kg) inhibits seawater instillation-induced increases in TNF-α, IL-1β, and IL-6 levels in lung tissue and white blood cell numbers in bronchoalveolar lavage fluid (BALF) and prevents lung edema in a rat model of acute lung injury. It reverses hepatic steatosis in a mouse model of high-fat diet-induced obesity when administered via a subcutaneous implant at a dose of 350 µg/day for two weeks. Levels of 4-hydroxyphenylacetic acid are increased and decreased in serum and urine, respectively, in rats fed a high-fat diet. Serum levels of 4-hydroxyphenylacetic acid are increased in patients with stage III pancreatic cancer.

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