We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman Etravirine
List Price $442.00 Your Price $442.00
Cayman Etravirine - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20946-50
MFG.PART: 20946-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Etravirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI).1 It is active against the wild-type HIV-1 strains LAI, SF2, and Ba-L (EC50s = 1.4-4.8 nM) but not the HIV-2 strain ROD (EC50 = 3,479 nM). Etravirine is also active against 18 HIV-1 strains carrrying NNRTI resistance-associated mutations (EC50s = <5 nM). Etravirine (5 μM) increases intracellular processing of the viral polyproteins Gag and Gag-Pol and decreases viral particle production in HEK293T cells transfected with a plasmid encoding the NL4.3 infectious molecular clone of HIV-1.2 Formulations containing etravirine have been used in the treatment of HIV-1 infection.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[[6-amino-
CAS Number
269055-15-4
Synonyms
- R165335
- TMC125
Molecular Formula
C20H15BrN6O
Formula Weight
435.3
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2) (1:3): 0.25 mg/mL
- DMSO: 20 mg/mL
λmax
234, 310 nm
SMILES
CC1=CC(C#N)=CC(C)=C1OC2=NC(NC3=CC=C(C#N)C=C3)=NC(N)=C2Br
InChi Code
InChI=1S/C20H15BrN6O/c1-11-7-14(10-23)8-12(2)17(11)28-19-16(21)18(24)26-20(27-19)25-15-5-3-13(9-22)4-6-15/h3-8H,1-2H3,(H3,24,25,26,27)
InChi Key
PYGWGZALEOIKDF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20946-50 |
|---|---|
| Supplier Part Number | 20946-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 269055-15-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |