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Cayman Atorvastatin lactone
List Price
$186.00
Your Price
$186.00
Cayman Atorvastatin lactone - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-20951-10
MFG.PART:
20951-10
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Atorvastatin lactone is an active metabolite of the HMG-CoA reductase inhibitor atorvastatin.1,2 It is formed from atorvastatin by the UDP-glucuronosyltransferase (UGT) isoforms UGT1A3 and UGT1A1 in insect cell-derived supersomes expressing the human enzymes, and hydrolyzes to form atorvastatin in human serum at room temperature.2,3 Atorvastatin lactone inhibits HMG-CoA reductase (IC50 = 0.007 µM for the rat liver enzyme).1 It also inhibits the cytochrome P450 (CYP) isoforms CYP2C9.1 and CYP2C9.3 (IC50s = 16.8 and 5.62 µM, respectively), as well as P-glycoprotein (P-gp; IC50 = 3.1-5.2 µM).4,5
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(4-fluoro
CAS Number
125995-03-1
Molecular Formula
C33H33FN2O4
Formula Weight
540.6
Purity
≥95%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 25 mg/mL
- DMF:PBS (pH 7.2) (1:3): 0.25 mg/mL
- DMSO: 15 mg/mL
- Ethanol: 10 mg/mL
λmax
248 nm
SMILES
O=C(C1=C(C(C)C)N(CC[C@H](C[C@@H](O)C2)OC2=O)C(C3=CC=C(F)C=C3)=C1C4=CC=CC=C4)NC5=CC=CC=C5
InChi Code
InChI=1S/C33H33FN2O4/c1-21(2)31-30(33(39)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-27-19-26(37)20-28(38)40-27/h3-16,21,26-27,37H,17-20H2,1-2H3,(H,35,39)/t26-,27-/m1/s1
InChi Key
OUCSEDFVYPBLLF-KAYWLYCHSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20951-10 |
|---|---|
| Supplier Part Number | 20951-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 125995-03-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |