We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman PQ401
List Price $587.00 Your Price $587.00
Cayman PQ401 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20979-50
MFG.PART: 20979-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
PQ401 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R).1 It inhibits autophosphorylation of the recombinant IGF-1R kinase domain (IC50 = <1 μM) in a cell-free assay as well as IGF-1-stimulated IGF-1R autophosphorylation in MCF-7 cells (IC50 = 12 μM). PQ401 reduces cell viability of U87MG glioma cells with an IC50 value of 5 μM and induces apoptosis and inhibits cell migration in a concentration-dependent manner.2 It inhibits IGF-1-stimulated proliferation of MCF-7 cells in vitro (IC50 = 6 μM) and reduces tumor growth in an MCNeuA model of murine breast cancer when administered at doses of 50 and 100 mg/kg.1 PQ401 also has antimalarial activity against the P. falciparum strain 3D7 (EC50 = 53 nM).3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(5-chloro-
CAS Number
196868-63-0
Molecular Formula
C18H16ClN3O2
Formula Weight
341.8
Purity
≥98%
Formulation(Request formulation change)
A solid
Solubility(Learn about Variance in Solubility)
- DMSO: 50 mm
- Ethanol: 25 mm
SMILES
CC1=NC2=CC=CC=C2C(NC(NC3=C(OC)C=CC(Cl)=C3)=O)=C1
InChi Code
InChI=1S/C18H16ClN3O2/c1-11-9-15(13-5-3-4-6-14(13)20-11)21-18(23)22-16-10-12(19)7-8-17(16)24-2/h3-10H,1-2H3,(H2,20,21,22,23)
InChi Key
YBLWOZUPHDKFOT-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20979-50 |
|---|---|
| Supplier Part Number | 20979-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 196868-63-0 |
| Energy Star | No |
| Green | No |
| Controlled | N |