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Cayman Nisoldipine
List Price $156.00 Your Price $156.00
Cayman Nisoldipine - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-20998-1
MFG.PART: 20998-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Nisoldipine is a calcium channel inhibitor. It binds to calcium channels in isolated rat ventricular membranes (Kd = 0.04 nM) and inhibits calcium uptake by smooth muscle cells., Nisoldipine inhibits acetylcholine-induced contraction of isolated rabbit coronary arteries (IC50 = 0.03 nM). In vivo, nisoldipine (3 mg/kg) reduces ventricular tachycardia and fibrillization and increases survival in a rat model of ventricular arrhythmias induced by myocardial ischemia. Dietary administration of nisoldipine (50-100 mg/kg) reduces systolic blood pressure in spontaneously hypertensive rats. Formulations containing nisoldipine have been used in the treatment of hypertension.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,4-dihydro-
CAS Number
63675-72-9
Synonyms
- (±)-BAY-K-5552
- (±)-Nisoldipine
Molecular Formula
C20H24N2O6
Formula Weight
388.4
Purity
≥97%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:10): 0.1 mg/mL
- Ethanol: 3 mg/mL
λmax
235, 330 nm
SMILES
CC(N([H])C(C)=C1C(OCC(C)C)=O)=C(C(OC)=O)C1C2=C([N+]([O-])=O)C=CC=C2
InChi Code
InChI=1S/C20H24N2O6/c1-11(2)10-28-20(24)17-13(4)21-12(3)16(19(23)27-5)18(17)14-8-6-7-9-15(14)22(25)26/h6-9,11,18,21H,10H2,1-5H3
InChi Key
VKQFCGNPDRICFG-UHFFFAOYSA-N
Shipping & Storage Information
Storage
Room temperature
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-20998-1 |
|---|---|
| Supplier Part Number | 20998-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | 22 |
| Refrigerated-Frozen | N |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | Y |
| CAS Number | 63675-72-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |