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Cayman SD-1029
List Price $36.00 Your Price $36.00
Cayman SD-1029 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21029-1
MFG.PART: 21029-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
SD-1029 is a Janus kinase 2 (JAK2) inhibitor., It inhibits autophosphorylation of recombinant JAK2 when used at concentrations of 30 and 100 μM and decreases levels of phosphorylated JAK2, but not JAK1 or Src, in MDA-MB-468 and paclitaxel-resistant OVCAR8TR cells when used at a concentration of 10 μM. SD-1029 (10 μM) decreases levels of phosphorylated STAT3 in MDA-MB-468, MDA-BM-435, OVCAR8TR, and SKOV3TR cells and inhibits IL-6-induced nuclear translocation of STAT3 in BHK-21 and U2OS cells. It decreases the viability of and increases levels of cleaved caspase-3 in SNU-387, SNU-398, HepG2, and Huh7 hepatocellular carcinoma cells when used at a concentration of 10 μM. SD-1029 (100 and 1,000 nM) inhibits hepatitis A virus replication in GL37 cells.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
9-(3,4-
CAS Number
118372-34-2
Synonyms
- JAK2 Inhibitor III
- Janus-Associated Kinase 2 Inhibitor III
Molecular Formula
C25H30Cl2N2O3 • 2HBr
Formula Weight
639.3
Purity
≥80% (mixture of isomers)
Formulation
A solid
Solubility
- DMSO: 10 mg/mL
SMILES
ClC1=C(Cl)C=CC(C2C3=C(CCC(CN(C)C)C3=O)OC4=C2C(C(CN(C)C)CC4)=O)=C1.Br.Br
InChi Code
InChI=1S/C25H30Cl2N2O3.2BrH/c1-28(2)12-15-6-9-19-22(24(15)30)21(14-5-8-17(26)18(27)11-14)23-20(32-19)10-7-16(25(23)31)13-29(3)4;;/h5,8,11,15-16,21H,6-7,9-10,12-13H2,1-4H3;2*1H
InChi Key
INKLAKXQHDQKKZ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21029-1 |
|---|---|
| Supplier Part Number | 21029-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 118372-34-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |