Cayman A-1210477

A-1210477 is an inhibitor of the antiapoptotic Bcl-2 family protein myeloid cell leukemia-1 (Mcl-1; K_i = 0.43 nM and IC₅₀ = 26.2 nM) that demonstrates >100-fold selectivity over other Bcl-2 family members (K_is > 0.66 µM for Bcl-2, Bcl-XL, Bcl-W, and Bfl-1).^,, It has been shown to disrupt the interaction between Mcl-1 and pro-apoptotic BIM, inducing the hallmarks of apoptosis in Mcl-1-dependent multiple myeloma and non-small cell lung cancer cell lines.^,

WARNING This product is not for human or veterinary use.