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Cayman A-1210477
List Price $128.00 Your Price $128.00
Cayman A-1210477 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21113-10
MFG.PART: 21113-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
A-1210477 is an inhibitor of the antiapoptotic Bcl-2 family protein myeloid cell leukemia-1 (Mcl-1; Ki = 0.43 nM and IC50 = 26.2 nM) that demonstrates >100-fold selectivity over other Bcl-2 family members (Kis > 0.66 µM for Bcl-2, Bcl-XL, Bcl-W, and Bfl-1).1,2,3 It has been shown to disrupt the interaction between Mcl-1 and pro-apoptotic BIM, inducing the hallmarks of apoptosis in Mcl-1-dependent multiple myeloma and non-small cell lung cancer cell lines.1,3
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
7-[5-[[4-[4-
CAS Number
1668553-26-1
Molecular Formula
C46H55N7O7S
Formula Weight
850.0
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: Slightly
- DMSO: Slightly
- Ethanol: Slightly
SMILES
CN(C)S(N1CCN(C2=CC=C(OCC3=C(C4=CC=CC5=C4N(CCN6CCOCC6)C(C(O)=O)=C5CCCOC7=C(C=CC=C8)C8=CC=C7)C(C)=NN3C)C=C2)CC1)(=O)=O
InChi Code
InChI=1S/C46H55N7O7S/c1-33-43(41(49(4)47-33)32-60-36-19-17-35(18-20-36)51-22-24-52(25-23-51)61(56,57)48(2)3)40-14-8-13-38-39(15-9-29-59-42-16-7-11-34-10-5-6-12-37(34)42)45(46(54)55)53(44(38)40)26-21-50-27-30-58-31-28-50/h5-8,10-14,16-20H,9,15,21-32H2
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21113-10 |
|---|---|
| Supplier Part Number | 21113-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1668553-26-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |