Cayman Zymosan A

Zymosan A is a glucan derived from the cell wall of S. cerevisiae that activates toll-like receptor 2 (TLR2) and a C-type lectin, dectin-1, on macrophages, monocytes, and dendritic cells to induce inflammatory signaling.^1,2,3,4 It is commonly used to stimulate a sterile inflammatory response in mouse models of sepsis, shock, and peritonitis.^5,6 In a mouse model of sepsis/shock, a lethal dose of zymosan A (500 mg/kg) in rats induced inflammation and shock leading to death.⁵ Zymosan A can also induce biosynthesis of eicosanoids.⁷

WARNING This product is not for human or veterinary use.