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Cayman DR2313
List Price $36.00 Your Price $36.00
Cayman DR2313 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21181-1
MFG.PART: 21181-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
DR2313 is an inhibitor of poly(ADP-ribose) polymerase (PARP; IC50 = 0.2 and 0.24 µM for PARP1 and PARP2, respectively, in nuclear rat brain extracts). It is selective for PARP, with no effect on GAPDH, ADH, LDH, or on lipid peroxidation. DR2313 is competitive with NAD+ at the catalytic site of PARP with a Ki value of 0.23 µM. Pretreatment of primary rat cortical cultures prevents cell death (EC50 = 0.27 µM), and, in vivo, it reduces infarct volume in a rat model of cerebral ischemia. DR2313 has been used to investigate cell death after middle cerebral artery occlusion.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
3,5,7,8-
CAS Number
284028-90-6
Synonyms
- PARP Inhibitor XI
Molecular Formula
C8H10N2OS
Formula Weight
182.2
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 10 mg/mL
- DMSO: 20 mg/mL
- Ethanol: 2 mg/mL
- PBS (pH 7.2): 0.3 mg/mL
λmax
229, 273 nm
SMILES
O=C(N=C(C)N1)C2=C1CCSC2
InChi Code
InChI=1S/C8H10N2OS/c1-5-9-7-2-3-12-4-6(7)8(11)10-5/h2-4H2,1H3,(H,9,10,11)
InChi Key
HRYKZAKEAVZGJD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21181-1 |
|---|---|
| Supplier Part Number | 21181-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 284028-90-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |