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Cayman NVP-BEZ235 (hydrochloride)
List Price $135.00 Your Price $135.00
Cayman NVP-BEZ235 (hydrochloride) - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21185-50
MFG.PART: 21185-50
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
NVP-BEZ235 is a potent dual inhibitor of phosphatidylinositol 3-kinase (PI3K) and mTOR that is well tolerated, displays disease stasis when administered orally, and enhances the efficacy of other anticancer agents when used in in vivo combination studies.1,2 It inhibits PI3K isoforms and mutants with low nanomolar IC50 values, leading to growth arrest in the g1 phase.1,3 Through its effects on PI3K, NVP-BEZ235 inhibits VEGF-induced angiogenesis.4 By directly blocking cell growth and indirectly inhibiting angiogenesis, it has potential in both solid tumors and in metastatic melanoma therapy.5,6
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-[2,3-
CAS Number
2319647-83-9
Synonyms
- Dactolisib
Molecular Formula
C30H23N5O • HCl
Formula Weight
506.0
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 0.5 mg/mL
- DMSO: 1 mg/mL
- Ethanol: 0.5 mg/mL
λmax
267 nm
SMILES
CN(C1=C(N2C3=CC=C(C(C)(C)C#N)C=C3)C4=CC(C5=CC(C=CC=C6)=C6N=C5)=CC=C4N=C1)C2=O.Cl
InChi Code
InChI=1S/C30H23N5O.ClH/c1-30(2,18-31)22-9-11-23(12-10-22)35-28-24-15-19(21-14-20-6-4-5-7-25(20)32-16-21)8-13-26(24)33-17-27(28)34(3)29(35)36;/h4-17H,1-3H3;1H
InChi Key
VDZVGMJFBACERH-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21185-50 |
|---|---|
| Supplier Part Number | 21185-50 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 2319647-83-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |