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Cayman CAY10796
List Price $94.00 Your Price $94.00
Cayman CAY10796 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21190-1
MFG.PART: 21190-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CAY10796 is an aminopyrazole ATP-competitive inhibitor of glycogen synthase kinase 3 (GSK3), with 34% inhibition when used at a concentration of 2.5 µM. It inhibits androgen receptor transactivation in 22Rv1, LNCaP, and LNCaP-SSR cell lines in a dose-dependent manner. It promotes nuclear export of the androgen receptor and decreases translocation to the nucleus in PC3 and PCa prostate cancer cells, respectively., In HEK293 cells expressing the rat Nav1.2 channel, pretreatment with CAY10796 dose-dependently potentiates peak current densities.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-(5-methyl-1H-pyrazol-3-yl)-2-phenyl-4-quinazolin
CAS Number
404828-14-4
Molecular Formula
C18H15N5
Formula Weight
301.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 0.25 mg/mL
- DMSO: 0.15 mg/mL
λmax
210, 249, 331 nm
SMILES
CC1=CC(NC2=NC(C3=CC=CC=C3)=NC4=C2C=CC=C4)=NN1
InChi Code
InChI=1S/C18H15N5/c1-12-11-16(23-22-12)20-18-14-9-5-6-10-15(14)19-17(21-18)13-7-3-2-4-8-13/h2-11H,1H3,(H2,19,20,21,22,23)
InChi Key
JYCUVOXSZBECAY-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21190-1 |
|---|---|
| Supplier Part Number | 21190-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 404828-14-4 |
| Energy Star | No |
| Green | No |
| Controlled | N |