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Cayman Necrostatin-1 Inactive Control
List Price $129.00 Your Price $129.00
Cayman Necrostatin-1 Inactive Control - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21192-5
MFG.PART: 21192-5
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Necrostatin-1 Inactive Control (Nec-1i) is a demethylated variant of necrostatin-1 (Nec-1; Item No. 11658), a RIP1 kinase inhibitor.1 While both Nec-1 and Nec-1i inhibit the immune regulator indoleamine 2,3-dioxygenase, Nec1i is ~100-fold less effective than Nec-1 in inhibiting RIP1 kinase in vitro and 10-fold less potent than Nec-1 in a mouse necroptosis assay.2 However, equally high doses of Nec-1 and Nec-1i are reported to inhibit TNF-induced systemic inflammatory response syndrome in vivo.2 Nec-1i is often used as an inactive control in studies using Nec-1 to exclude nonspecific off-target effects.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-(1H-indol-
CAS Number
64419-92-7
Synonyms
- Nec-1i
- Nec-1 Inactive Control
Molecular Formula
C12H11N3OS
Formula Weight
245.3
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 20 mg/mL
- DMF:PBS (pH 7.2) (1:1): 0.5 mg/mL
- DMSO: 14 mg/mL
- Ethanol: 3 mg/mL
λmax
220, 267 nm
SMILES
O=C(C(N1)CC2=CNC3=CC=CC=C32)NC1=S
InChi Code
InChI=1S/C12H11N3OS/c16-11-10(14-12(17)15-11)5-7-6-13-9-4-2-1-3-8(7)9/h1-4,6,10,13H,5H2,(H2,14,15,16,17)
InChi Key
MPLRRPKKFHUEEL-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21192-5 |
|---|---|
| Supplier Part Number | 21192-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 64419-92-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |