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Cayman CDK/CRK Inhibitor
List Price $203.00 Your Price $203.00
Cayman CDK/CRK Inhibitor - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21195-1
MFG.PART: 21195-1
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CDK/CRK inhibitor is an inhibitor of cyclin-dependent kinases (CDK) and CDK-related kinases (CRK) with IC50 values ranging from 9-839 nM in vitro. It is selective, exhibiting less than 20% inhibition of 60 non-CDK/CRK kinases, at a concentration of 1 μM. CDK/CRK inhibitor induces cell cycle arrest in the g1 phase, endoreduplication, and apoptosis in HCT116 cells. It exhibits broad anti-tumor activity with an average GI50 value of <10 nM for 60 tumorigenic cell lines. It also inhibits growth of non-cycling HCT116 cells with an IC50 value of 40 nM.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1-(2,6-di
CAS Number
784211-09-2
Synonyms
- Cdk7 Inhibitor IV
- Cyclin-dependent kinase 7 Inhibitor IV
- Cyclin-dependent kinase/CDK-related kinase Inhibitor
- RGB-286147
Molecular Formula
C23H22Cl2N4O3
Formula Weight
473.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 30 mg/mL
- DMSO: 30 mg/mL
- DMSO:PBS (pH 7.2) (1:4): 0.2 mg/mL
λmax
214 nm
SMILES
O=C1C2=C(N(C3=C(Cl)C=CC=C3Cl)N=C2C(C)C)NC(CC4=CC=C(OCCO)C=C4)=N1
InChi Code
InChI=1S/C23H22Cl2N4O3/c1-13(2)20-19-22(29(28-20)21-16(24)4-3-5-17(21)25)26-18(27-23(19)31)12-14-6-8-15(9-7-14)32-11-10-30/h3-9,13,30H,10-12H2,1-2H3,(H,26,27,31)
InChi Key
RSQPNXBTPUXMQN-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21195-1 |
|---|---|
| Supplier Part Number | 21195-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 784211-09-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |