We use cookies to make your experience better. To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn about our cookie policy.
Cayman CYC-116
List Price $103.00 Your Price $103.00
Cayman CYC-116 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21205-10
MFG.PART: 21205-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
CYC-116 is a potent Aurora kinase inhibitor exhibiting Ki values of 8.0 and 9.2 nM for Aurora kinases A and B, respectively.1 It is significantly less potent against a panel of cyclin-dependent kinases and other related kinases, with the exception of Flt-3 (Ki = 44 nM). CYC-116 exhibits broad-spectrum antiproliferative activity against a panel of human cancer cell lines with a mean IC50 value of 0.54 µM (range = 0.09 – 1.6 µM). It is orally bioavailable and inhibits the growth of human tumor xenografts in mice.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
4-(2-amino-4-
CAS Number
693228-63-6
Molecular Formula
C18H20N6OS
Formula Weight
368.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 1.25 mg/mL
- DMSO: 10 mg/mL
- DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL
λmax
295, 337 nm
SMILES
CC(N=C(N)S1)=C1C2=NC(NC3=CC=C(N4CCOCC4)C=C3)=NC=C2
InChi Code
InChI=1S/C18H20N6OS/c1-12-16(26-17(19)21-12)15-6-7-20-18(23-15)22-13-2-4-14(5-3-13)24-8-10-25-11-9-24/h2-7H,8-11H2,1H3,(H2,19,21)(H,20,22,23)
InChi Key
GPSZYOIFQZPWEJ-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21205-10 |
|---|---|
| Supplier Part Number | 21205-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 693228-63-6 |
| Energy Star | No |
| Green | No |
| Controlled | N |