Cayman Streptomycin (sulfate)

Streptomycin is an aminoglycoside antibiotic that inhibits growth of both Gram-negative (MICs = 1 and 16 μg/mL for K. pneumoniae and S. marcescens, respectively) and Gram-positive bacteria (MIC = 0.25 μg/mL for S. pneumoniae). It inhibits growth of M. tuberculosis H37Rv (MIC = 5 μg/mL) and of susceptible strains from clinical isolates (MICs = ≤0.125-1 μg/mL).^, Streptomycin (150 mg/kg), in combination with isoniazid (Item No. ), rifapentine (Item No. ), and moxifloxacin (Item No. ), administered once per week over 6 months to M. tuberculosis-inoculated mice results in clearance of the pathogen from the lungs of the majority of treated mice. However, after 3 months without treatment, 58% of treated mice produce a positive lung culture. Streptomycin acts by inhibiting protein synthesis in prokaryotes by binding to the 30S ribosomal subunit.^,,, It has been used, in combination with penicillin g (Item No. ), in antibiotic cocktails to prevent bacterial growth in cell culture. Formulations containing streptomycin in combination with other antibiotics have been used to treat tuberculosis.

WARNING This product is not for human or veterinary use.