Cayman Dienogest

Dienogest is a synthetic progestin and progesterone receptor (PR) agonist (EC₅₀s = 3.4-10.5 nM in transactivation assays).¹ It is selective for PR over estrogen receptor α (ERα) and ERβ, as well as glucocorticoid and mineralocorticoid receptors (EC₅₀s = >3,000 nM for all), as well as sex hormone-binding globulin (SHBG) and cortisol-binding globulin (CBG; IC₅₀s = 900-950 and 7,970 nM, respectively, in radioligand binding assays). It also inhibits dihydrotestosterone-induced transactivation of the androgen receptor (EC₅₀s = 420.6-775 nM). Dienogest (0.1, 0.3, and 1 mg/kg per day for 21 days, p.o.) reduces lesion formation in a rat model of endometriosis.² It reduces 17β-estradiol benzoate-dependent tumor growth in an MCF-7 ovariectomized mouse xenograft model when administered at doses of 0.1 and 1 mg/kg per day for 28 days.³ Formulations containing dienogest in combination with estradiol valerate have been used as contraceptives.

WARNING This product is not for human or veterinary use.