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Cayman MK-1775
List Price $86.00 Your Price $86.00
Cayman MK-1775 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21266-10
MFG.PART: 21266-10
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
MK-1775 is an inhibitor of the checkpoint kinase Wee1 (IC50 = 5.2 nM). It has been shown to inhibit the phosphorylation of Cdc2 at tryosine-15, which abrogates the g2 DNA damage checkpoint. In p53-deficient tumors that rely solely on the g2 checkpoint upon DNA damage, MK-1775, in combination with DNA-damaging chemotherapeutic agents, is reported to induce apoptosis in vitro and potentiate the inhibition of tumor growth in vivo.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
1,2-dihydro-
CAS Number
955365-80-7
Synonyms
- AZD 1775
Molecular Formula
C27H32N8O2
Formula Weight
500.6
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMSO: ~80 mg/mL
λmax
229, 257, 292 nm
SMILES
CN1CCN(C2=CC=C(NC3=NC=C(C(N(CC=C)N4C5=CC=CC(C(C)(O)C)=N5)=O)C4=N3)C=C2)CC1
InChi Code
InChI=1S/C27H32N8O2/c1-5-13-34-25(36)21-18-28-26(29-19-9-11-20(12-10-19)33-16-14-32(4)15-17-33)31-24(21)35(34)23-8-6-7-22(30-23)27(2,3)37/h5-12,18,37H,1,13-17H2,2-4H3,(H,28,29,31)
InChi Key
BKWJAKQVGHWELA-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21266-10 |
|---|---|
| Supplier Part Number | 21266-10 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 955365-80-7 |
| Energy Star | No |
| Green | No |
| Controlled | N |