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Cayman PT1
List Price
$41.00
Your Price
$41.00
Cayman PT1 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-21335-1
MFG.PART:
21335-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
PT1 is an activator of AMP-activated protein kinase (AMPK) that directly activates the inactive truncated forms of AMPK monomers α1335, α1394, and α2398 in a dose-dependent manner (EC50s = ~ 8, 8, and 12 µM, respectively). It stimulates the α1β1γ1 AMPK heterotrimer with an EC50 value of 0.3 μM. PT1 dose-dependently increases phosphorylation of AMPK and its downstream substrate, acetyl-CoA carboxylase, without increasing the cellular AMP:ATP ratio in L6 myotubes. In HepG2 liver cells, PT1 lowers lipid content through AMPK activation. PT1 induces autophagy in cardiomyocytes after oxygen glucose deprivation/reoxygenation, resulting in improved cell survival.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-chloro-5-[[
CAS Number
331002-70-1
Molecular Formula
C23H16ClN3O6S
Formula Weight
497.9
Purity
≥95%
Formulation
A crystalline solid
Solubility
- DMF: 1 mg/mL
- DMSO: 1 mg/mL
- DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
- Ethanol: slightly
λmax
272, 399 nm
SMILES
ClC1=CC=C(NC(S/C2=C/C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)=NC2=O)C=C1C(O)=O
InChi Code
InChI=1S/C23H16ClN3O6S/c1-11-7-16(18(27(31)32)8-12(11)2)19-6-4-14(33-19)10-20-21(28)26-23(34-20)25-13-3-5-17(24)15(9-13)22(29)30/h3-10H,1-2H3,(H,29,30)(H,25,26,28)/b20-10+
InChi Key
RTHRCOIONCZINZ-KEBDBYFISA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21335-1 |
|---|---|
| Supplier Part Number | 21335-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 331002-70-1 |
| Energy Star | No |
| Green | No |
| Controlled | N |