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Cayman Metergoline
List Price $219.00 Your Price $219.00
Cayman Metergoline - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21336-100
MFG.PART: 21336-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
Metergoline is a serotonin (5-HT) receptor antagonist that is active at 5-HT1 (pKi = 7.8 for 5-HT1B), 5-HT2, (pKi = 8.64, 8.75, and 8.75 for 5-HT2A, 5-HT2B, and 5-HT2C respectively), and 5-HT7 receptor subtypes.1,2 It blocks 5-HT7 receptor-stimulated cAMP production (IC50 = 321 nM) in HEK293 cells.3 Metergoline has been widely used to study serotonin receptor function, but it also dose-dependently inhibits voltage-dependent sodium and potassium channels transfected into Xenopus oocytes.4,5 Formulations containing metergoline have been studied for the treatment of hormone dysfunction, seasonal affective disorder, and anxiety.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
N-[[(8β)-1,6-
CAS Number
17692-51-2
Molecular Formula
C25H29N3O2
Formula Weight
403.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF:PBS(pH7.2) (1:2): 0.3 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 5 mg/mL
λmax
226, 289 nm
SMILES
CN1C2=CC=CC([C@@]3([H])C[C@@H](CNC(OCC4=CC=CC=C4)=O)CN(C)[C@]3([H])C5)=C2C5=C1
InChi Code
InChI=1S/C25H29N3O2/c1-27-14-18(13-26-25(29)30-16-17-7-4-3-5-8-17)11-21-20-9-6-10-22-24(20)19(12-23(21)27)15-28(22)2/h3-10,15,18,21,23H,11-14,16H2,1-2H3,(H,26,29)/t18-,21+,23+/m0/s1
InChi Key
WZHJKEUHNJHDLS-QTGUNEKASA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21336-100 |
|---|---|
| Supplier Part Number | 21336-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 17692-51-2 |
| Energy Star | No |
| Green | No |
| Controlled | N |