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Cayman PA-457
List Price
$139.00
Your Price
$139.00
Cayman PA-457 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-21339-5
MFG.PART:
21339-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
PA-457 is an inhibitor of HIV-1 virion maturation.1,2 It inhibits the cleavage of the Gag capsid (CA) precursor CA-SP1 to the mature CA protein. PA-457 inhibits the replication of drug-sensitive and -resistant clinical isolates of HIV-1 in isolated human peripheral blood mononuclear cells (PBMCs; mean IC50s = 10.3 and 7.8 nM, respectively).3 In vivo, it prevents replication of HIV-1 in SCID-hu Thy/Liv mice when administered at a dose of 100 mg/kg.4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
(3β)-3-(3-
CAS Number
174022-42-5
Synonyms
- 3-O-(3,3-Dimethylsuccinyl) Betulinic Acid
- Bevirimat
- FH11327
- MPC-4326
Molecular Formula
C36H56O6
Formula Weight
584.8
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 30 mg/mL
- DMF:PBS (pH 7.2)(1:3): 0.25 mg/mL
- DMSO: 25 mg/mL
- Ethanol: 2.5 mg/mL
SMILES
[H][C@]1([C@H](C(C)=C)CC2)[C@@]2(C(O)=O)CC[C@]3(C)[C@]1([H])CC[C@@]4([H])[C@@]3(C)CC[C@]5([H])[C@]4(C)CC[C@H](OC(CC(C)(C)C(O)=O)=O)C5(C)C
InChi Code
InChI=1S/C36H56O6/c1-21(2)22-12-17-36(30(40)41)19-18-34(8)23(28(22)36)10-11-25-33(7)15-14-26(42-27(37)20-31(3,4)29(38)39)32(5,6)24(33)13-16-35(25,34)9/h22-26,28H,1,10-20H2,2-9H3,(H,38,39)(H,40,41)/t22-,23+,24-,25+,26-,28+,33-,34+,35+,36-/m0/s1
InChi Key
YJEJKUQEXFSVCJ-WRFMNRASSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21339-5 |
|---|---|
| Supplier Part Number | 21339-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 174022-42-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |