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Cayman NMS-P118
List Price
$41.00
Your Price
$41.00
Cayman NMS-P118 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-21340-1
MFG.PART:
21340-1
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
NMS-P118 is an orally bioavailable, potent, and selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1), which is an enzyme activated by DNA damage and is critical for the repair of DNA single-strand breaks via the base excision repair pathway., NMS-P118 is selective for PARP1 (Kd = 9 nM) over PARP2 (Kd = 1,390 nM). It is efficacious in MDA-MD-436 human breast and Capan-1 human pancreatic cancer mouse xenograft models.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
2-[1-(4,4-
CAS Number
1262417-51-5
Molecular Formula
C20H24F3N3O2
Formula Weight
395.4
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 5 mg/mL
- DMSO: 2 mg/mL
- Ethanol: slightly soluble
λmax
294 nm
SMILES
FC1(F)CCC(N2CCC(N(CC3=C4C(C(N)=O)=CC(F)=C3)C4=O)CC2)CC1
InChi Code
InChI=1S/C20H24F3N3O2/c21-13-9-12-11-26(19(28)17(12)16(10-13)18(24)27)15-3-7-25(8-4-15)14-1-5-20(22,23)6-2-14/h9-10,14-15H,1-8,11H2,(H2,24,27)
InChi Key
ARYVAQSYRLZVQD-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Wet ice in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21340-1 |
|---|---|
| Supplier Part Number | 21340-1 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 1262417-51-5 |
| Energy Star | No |
| Green | No |
| Controlled | N |