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Cayman Dcp-La; Purity- Greater Than Or Equal To 95%; Size- 5 Mg;
List Price
$632.00
Your Price
$632.00
Cayman Dcp-La; Purity- Greater Than Or Equal To 95%; Size- 5 Mg; - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART:
CAYM-21375-5
MFG.PART:
21375-5
UNSPSC:
12352200
Manufacturer:
Cayman
Product Description
Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3; IC50s = 10.7 and 13.2 μM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 μM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 μM) increases contractile tension in isolated ventricular muscles of dog, cat, rabbit, and guinea pig in a dose-dependent manner. Oral and i.v. administration of vesnarinone increases right ventricular pressure with no effect on heart rate in dog models of tricuspid insufficiency- and pulmonary stenosis-induced congestive heart failure. It also increases contractility and coronary flow while decreasing heart rate in a guinea pig model of aortic stenosis-induced congestive heart failure. Formulations containing vesnarinone have been used for the treatment of congestive heart failure.
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
6-[4-(3,4-
CAS Number
81840-15-5
Synonyms
- OPC 8212
Molecular Formula
C22H25N3O4
Formula Weight
395.5
Purity
≥98%
Formulation
A crystalline solid
Solubility
- DMF: 3 mg/ml
- DMSO: 3 mg/ml
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
λmax
272 nm
SMILES
COC1=CC=C(C(N2CCN(C3=CC(CCC(N4)=O)=C4C=C3)CC2)=O)C=C1OC
InChi Code
InChI=1S/C22H25N3O4/c1-28-19-7-3-16(14-20(19)29-2)22(27)25-11-9-24(10-12-25)17-5-6-18-15(13-17)4-8-21(26)23-18/h3,5-7,13-14H,4,8-12H2,1-2H3,(H,23,26)
InChi Key
ZVNYJIZDIRKMBF-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21375-5 |
|---|---|
| Featured | No |
| Supplier Part Number | 21375-5 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Refrigerated |
| CountryOfOrigin | United States |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 2 |
| Hazardous | N |
| CAS Number | 28399-31-7 |
| Energy Star | No |
| Green | No |
| ACT Ecolabel | No |
| Controlled | N |