Cayman all-trans-4-hydroxy Retinoic Acid

all-trans-4-hydroxy Retinoic acid is a metabolite of all-trans retinoic acid (Item No. ) formed by the cytochrome P450 (CYP) isoforms CYP26A1, B1, and C1.^, It binds to retinoic acid receptors (RARs) with a lower affinity than other all-trans retinoic acid metabolites (IC₅₀s = 606, 298, and 892 nM for RARα, RARβ, and RARγ, respectively, in a radioligand binding assay). It also transactivates RARs with a lower efficacy than other metabolites (EC₅₀s = 791, 64, and 94 nM for RARα, RARβ, and RARγ, respectively) but induces transcription of a reporter plasmid equipotently. all-trans-4-hydroxy Retinoic acid inhibits cell growth, halts the cell cycle in the g₁ phase, and induces differentiation of NB4 acute promyelocytic leukemia cells (EC₅₀ = 79.8 nM).

WARNING This product is not for human or veterinary use.