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Cayman KX2-391
List Price $594.00 Your Price $594.00
Cayman KX2-391 - CAYM (Additional S&H Or Hazmat Fees May Apply)
NETA PART: CAYM-21429-100
MFG.PART: 21429-100
UNSPSC: 12352200
Manufacturer: Cayman
Product Description
KX2-391 is an inhibitor of Src kinase (IC50 = ~20 nM).1 It is selective for Src over PDGFR, EGFR, JAK1, JAK2, Lck, and ZAP-70. KX2-391 induces cell cycle arrest at the g2/M phase and apoptosis in breast cancer cells expressing estrogen receptor α (ERα).2 It inhibits the growth of Huh7, PLC/PRF/5, Hep3B, and HepG2 cells (GI50s = 9, 13, 26, and 60 nM, respectively).3 KX2-391 (10 mg/kg) decreases spleen weight and the number of splenic leukemia cells in a mouse model of FLT3 bearing internal-tandem duplication and F691L mutant (FLT3-ITD-F691L) acute myeloid leukemia (AML).4
WARNING This product is not for human or veterinary use.
Technical Information
Formal Name
5-[4-[2-(4-
CAS Number
897016-82-9
Synonyms
- KX 01
- Tirbanibulin
Molecular Formula
C26H29N3O3
Formula Weight
431.5
Purity
≥98%
Formulation(Request formulation change)
A crystalline solid
Solubility(Learn about Variance in Solubility)
- DMF: 10 mg/mL
- DMSO: 15 mg/mL
- DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL
- Ethanol: 1 mg/mL
λmax
268 nm
SMILES
O=C(CC1=NC=C(C2=CC=C(OCCN3CCOCC3)C=C2)C=C1)NCC4=CC=CC=C4
InChi Code
InChI=1S/C26H29N3O3/c30-26(28-19-21-4-2-1-3-5-21)18-24-9-6-23(20-27-24)22-7-10-25(11-8-22)32-17-14-29-12-15-31-16-13-29/h1-11,20H,12-19H2,(H,28,30)
InChi Key
HUNGUWOZPQBXGX-UHFFFAOYSA-N
Shipping & Storage Information
Storage
-20°C
Shipping
Room Temperature in continental US; may vary elsewhere
Stability
≥ 4 years
| SKU | CAYM-21429-100 |
|---|---|
| Supplier Part Number | 21429-100 |
| UM | EA |
| UNSPSC | 12352200 |
| Manufacturer | Cayman |
| MSDS URL | Click here |
| Temperature | -20 |
| Refrigerated-Frozen | Y |
| CountryOfOrigin | China |
| ProductLine | CAYM |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| CAS Number | 897016-82-9 |
| Energy Star | No |
| Green | No |
| Controlled | N |