Cayman CpdA

CpdA is a non-steroidal selective glucocorticoid receptor modulator. It is an aziridine precursor that can infiltrate cells and is translocated to the nucleus.^, It inhibits glucocorticoid receptor dimerization, which prevents transcription of gene targets such as NF-κB and subsequent cytokines through transrepression. Studies have shown contradictory results for binding affinity of CpdA compared with dexamethasone (Item No. ) that were either higher (4-fold, IC₅₀ = 6.4 nM and 25.9 nM, respectively, in L929sA cells) or lower (63-fold, K_d = 81.8 nM and 1.29 nM, respectively, in BWTG3 cells) in whole cell binding assays.^,

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